Non-epigenetic | Non-epigenetic | Non-epigenetic

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Extranodal NK-/T-Cell Lymphoma, Nasal Type
Primary Mediastinal (Thymic) Large B-Cell Lymphoma (PMBL)

BUB1-MGAT4A, CBFA2T3-ABHD12, NRAS Gln61Pro, TP53 Ile251Thr
KMT2A-MLLT3, EP300, KRAS and TP53 mutations
NUP214-ABL1, HNRNPC-ZNF219, NOTCH Leu1600Pro, TP53 Tyr163CysZNF219
Overexpression of TAL1 (no TAL1 abnormality or translocation of TAL1 locus)
PVT1-CCDC26,PML-RARA, KRAS Ala18Asp, TP53 Arg248Gln
RUNX1-RUNX1T1 (AML1-ETO), KIT N822K, RAD21 K330F, TP53 R248Q
STIL-TAL1 [PMID: 25394790 shows results of MOLT-3]
STIL-TAL1 [PMID: 35354797] and NKX2.5-BCL11B
TP53(del), CDKN2A and NRAS mutations [PubMed=288488], No PML-RARA fusion

PD Dr. M. Peitz (Bonn University, Institute of Reconstructive Neurobiology, Bonn, Germany)

Post-treatment cell line paired with pre-treatment cell line-ACH-003658 SK-N-BE(1)
Previously, ACH-000995 and ACH-003508 were noted to be derived from different patients. STR and SNP profiles indicate very high levels of relatedness. Relatedness should be assumed with caution.
Probably misclassified. Originally thought to be a leukemia cell line but is probably a B-lymphoblastoid cell line (PubMed=12592342).
SNP fingerprinting rules out contamination. Depmap has correct ATCC stock
SNP fingerprinting rules out SUM149PT contamination.
SNP fingerprinting rules out U-937 contamination.

501mel Human melanoma cell line (female); Obtained from Ruth Halaban, Yale;  Zakut et al., 1993
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: D19S433: 12,12.2->13,14 and D3S1358: 12,16->16,17.
Contrast consists of model combining multiple cell lines
https://pubmed.ncbi.nlm.nih.gov/30454645/
https://pubmed.ncbi.nlm.nih.gov/32295077/
Less differentiated subline of KG-1, composed of undifferentiated promyeloblasts.
Parent: CVCL_0291 (HCT 116)
PRJNA533647; GEO: GSE130054; hair follicle stem cells (HFSCs)
PRJNA592159; GEO: GSE141116
PRJNA670855; GEO: GSE159906
PRJNA752346; GEO: GSE181517
PRJNA760930; GEO: GSE183477; Huntsman Cancer Institute (HCI)-001 patient-derived organoids (PDOs) and HCI-002 PDOs obtained from Huntsman Cancer Institute, University of Utah
PRJNA763229; GEO: GSE184125
PRJNA814284; GEO: GSE198248
PRJNA846720; GEO: GSE205618
Problematic cell line: Contaminated. Shown to be a HK-2 derivative (CCRID). Originally thought to be a renal tubular epithelial cell line.
Problematic cell line: Misclassified. Originally thought to arise from a metastatic carcinoid of the terminal ileum but shown to be an EBV-transformed lymphoblastoid cell line (PubMed=29444910; PubMed=31548718). Although misidentified, it has been argued that transcriptional regulation of the cells enough resemble gastroenteropancreatic neuroendocrine tumors to be used in studies (PubMed=31548719).
Problematic cell line: Partially misidentified. For a period of time Asterand (now BioIVT) mistakenly distributed SUM149PT (Cellosaurus=CVCL_3422) under the designation of SUM229PE. This leads to the publication of a STR profile (PubMed=25877200) which was almost identical to that of SUM149PT.
The L0125, L0512, L0615, and L0627 GBM GSC lines were provided by Dr Rossella Galli (San Raffaele Scientific Institute, Milan, Italy)